Mona Yassine was appointed as the first Chairperson of the Egyptian Competition Authority on 20 August 2005, from which she retired on 11 January 2011. The Egyptian Competition Law was introduced in February of 2005.  Prior to that, she was the Vice Chairman at Banque du Caire, the third largest Egyptian bank, from 2002 to 2005, as part of the Government Bank Reform program. She also held the position of Chairwoman for the Cairo Far East Bank, an affiliate of Banque du Caire, until June 2006.  She worked for Citibank from 1977 to 2002, and assumed several positions and responsibilities which are Vice President and Senior Credit Officer – Citibank N.A. Egypt (a subsidiary of Citigroup), and held the job of the Country Risk Manager. Prior to Citibank, Mona held different administrative jobs in Egypt, Algeria, Syria and the UK.  

Mona Yassine headed the establishment of the first NGO in Egypt for the protection of competition, Association for the Protection of Competition- Egypt, and is currently the Vice Chairman of the organization. The NGO's founding members are 25 prominent lawyers, economists and news reporters; it received its license to operate in September 2011.

She is a non-executive Board Member of Banque du Caire.  She volunteers in an organization that helps the sustainable development of agricultural communities and provides consultation to a financial institution regarding their small and medium lending business.

Mona Yassine holds a B.A. in Economics from the American University in Cairo (AUC) and received a diploma in Investment Appraisal and Management from Harvard University.